The Effects of Statins on Renal Functions

Lipid metabolism disorder results in progression of chronic renal disease. Statins inhibit HMG-CoA reductase, that catalyzes the rate-limiting step in cholesterol biosynthesis and statins also decrease clinical risks related with atherosclerosis. In addition to lipidlowering effects, a multitude of potentially renal protective effects are being ascribed to statins in recent reports, including improved endothelial function, increased plaque stability, decreased monocyte migration, decreased mesengial matrix proliferation, and improved circulation. 

In this review, the pathogenesis of beneficial effect of statins are well examined and we present the reports which were investigated the effects of statins on renal functions.