Juvenile idiopathic arthritis (JIA), one of the most common rheumatic diseases of childhood, is characterized by chronic synovitis and other organ dysfunctions. The characteristic renal lesion in JIA is amyloidosis, usually associated with chronic disease activity but the disease may cause different clinical conditions varying from hematuria to obstructive uropathy. In this report we describe a child with systemic-onset juvenile idiopathic artrhritis and mesengioproliferative glomerulonephritis.