Aspergillus infections may present in a variety of conditions including chronic sinusitis and are rarely seen in individuals without immune deficiency. A 69-year-old male patient was seen because of continuing complaints of chronic sinusitis for 8 months and diagnosed as stage 3 chronic renal disease. The mass lesion in the left maxillary sinus not responding medical therapy was extracted surgically and diagnosed as maxillary sinus aspergilloma. Cellular and humoral immunity may fail in the course of chronic renal disease and opportunistic infections of atypical and rare agents may be seen.