Spontaneous renal artery dissection is a rare and serious event that can result in renal parenchymal injury and severe hypertension. We report a case of a 38-year-old previously healthy man who presented with unilateral flank pain and had a renal artery dissection complicated with renal infarction. Initial laboratory tests and urinalysis were essentially normal. An abdominal CT scan showed isolated right main renal artery dissection with thrombus and infarction. The renal angiography demonstrated a 60- 70% stenosis causing dissection with thrombus in the right main renal artery. The patient was treated with renal artery stenting and anticoagulant therapy.