Turkish Journal of Nephrology
Original Article

Vitamin D Receptor Polymorphisms in Overweight/Obese Chronic Kidney Disease Patients on Dialysis

1.

Department of Medical Biochemistry, Altinbaş University Faculty of Medicine, İstanbul, Türkiye

2.

Department of Nephrology, Hatay Training and Research Hospital, Hatay, Türkiye

3.

Department of Nutrition and Dietetics, Sivas Cumhuriyet University Faculty of Health Sciences, Sivas, Türkiye

4.

Division of Nephrology, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Türkiye

Turkish J Nephrol 2024; 33: 217-222
DOI: 10.5152/turkjnephrol.2023.23369
Read: 380 Downloads: 257 Published: 07 November 2023

Background: Little is known about the possible association of vitamin D receptor (VDR) gene polymorphisms in obese patients with chronic kidney disease on dialysis (CKD-G5D). Therefore, we aimed to investigate VDR gene TaqI, ApaI, and FokI singlenucleotide polymorphisms (SNPs) in overweight/obese CKD-G5D patients.

Methods: Seventy-one normal-weight and 68 overweight/obese CKD-G5D patients were included in the study. The polymerase chain reaction-restriction fragment length polymorphism method was used for genotyping. Demographic and laboratory data were obtained from the medical records of patients.

Results: For all 3 SNPs, no significant association was found between normal-weight and overweight/obese patients (P > .05). High-density lipoprotein (HDL) concentrations were lower, but triglyceride (TG) and glucose levels were higher in overweight/obese patients compared to normal-weight patients (P < .001 for HDL and TG and P = .023 for glucose). In overweight/obese patients, individuals with the TaqI CC genotype had higher (PTH) levels than those with TC and TT genotypes (CC = 717.1 ± 616.4, TC = 342.7 ± 360.8, and TT = 310.2 ± 323.4 pg/mL; P = .028). Similarly, patients with the ApaI genotype (627.3 ± 653.0 mg/dL) had higher TG levels than those with the AA and AC genotypes (CC = 627.3 ± 653.0, AA = 223.3 ± 156.6, AC = 193.1 ± 85.4; P < .001). Overweight/obese patients with the FokI TT genotype had higher glucose concentrations than those with the CC and CT genotypes (CC = 183.4 ± 128.4 mg/dL, TT = 151.9 ± 66.1 mg/dL, and CT = 107.6 ± 41.9 mg/dL; P = .008).

Conclusion: Our study suggests that VDR TaqI, ApaI, and FokI polymorphisms are not associated with obesity in CKD-G5D patients. However, they might increase the risk of secondary hyperparathyroidism, dyslipidemia, and hyperglycemia.

Cite this article as: Bağcı G, Hüzmeli C, Bağcı B, Candan F. Vitamin D receptor polymorphisms in overweight/obese chronic kidney disease patients on dialysis. Turk J Nephrol. 2024;33(2):217-222.

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