Turkish Journal of Nephrology
Original Article

THE EFFECT OF DONOR-SPECIFIC TRANSFUSIONS (DST) ON SHORT AND LONG-TERM RENAL ALLOGRAFT FUNCTION

1.

Ankara Üniversitesi Tıp Fakültesi Nefroloji Bilim Dalı, ANKARA

2.

Ankara Üniversitesi Tıp Fakültesi, Genel Cerrahi, ANKARA

3.

Ankara Üniversitesi Tıp Fakültesi, Üroloji Anabilim Dalı, ANKARA

4.

Ankara Üniversitesi Tıp Fakültesi, immünoloji Bilim Dalı, ANKARA

Turkish J Nephrol 1995; 4: 13-16
Read: 305 Downloads: 185 Published: 22 March 2019

In order to evaluate the effect of donor-speclflc blood transfusions (DST) on short- and long-term renal allograft function, a group consisted of 20 patients who underwent DST was compared to 35 patients who received HLA-identical living related donor graft and 25 patients who received one-haplotyplc donor graft.

After transplantation, the time in which serum creatinine levels returned to the normal range in DST (4.1 ± 2.3 days) and HLA-identical groups (4.3±2.6 days) was significantly shorter than those in the onehaplotype group (6.2 ± 3.2 days) (p<0.05). While in one patient of tHe DST group (5.0 %) and three patients of the HLA-identical group (8.6 %) the serum creatinine level was not decreased below to 1.5 mgldl, this number was six (24.0 %) in the one-haplotype group. In the first and second groups acute rejection incidence (respectively 25 % and 20 %) was lower than in the one-haplotype group (44 %), but these differences were not statistically significant. In the DST group three-year graft survival (85.7%) was similar to HLA-identical group (85.2 %), and better than the one-haplotype group (78.9 %).We conclude that results similar to HLA-identical transplantation may be obtained using the DST procedure in poorly matched donor and recipient combinations. 

Files
EISSN 2667-4440