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In this study, we investigated the prevalence, the probable risk factors and the clinical course of post transplant diabetes mellitus (PTDM).
In the June of 1994, we found 15 (6 %) PTDM patients among 225 renal allograft recipients. The mean appearance time of PTDM was 3.2 ±2.8 months. Five of them were treated by diet only, 6 received oral antidiabetic drugs and 4 needed insulin.
The fifteen PTDM patients were compared with 30 control cases randomly selected. Of the parameters investigated, only age and cumulative cyclosporin dose were identified as risk factors (p<0.001 and p<0.05 respectively). There was no statistically significant difference between the two groups with regard to the following parameters age, diabetic family history; serum creatinine value and body mass index at time of the diagnosis of PTDM, the increase in body weight from the time of transplantation to the appearance time of PTDM, cumulative doses of steroid.
22J±18 months after PTDM diagnosis, there was no statistically significant difference between the two groups' creatinine values (1.69±0.62 - 1.51+0.38 mgldL; 149.3+54.8 - 133.4+33.5 mmollL). PTDM did not appear to have any harmful effect on graft function in short term, but increased the predisposition to the urinary tract infection.