The risk of neoplasm increases after transplantation in patients with organ transplantation. Immunosuppressive treatments or oncogenic viruses are major risk factors. Epstein-Barr virus (EBV) and Human Herpesvirus-8 (HHV-8) are the most frequently shown types among oncogenic viruses. Herein, we present a case of spindle cell neoplasm in a 70-year-old renal transplant recipient who underwent immunosuppressive treatment for 4 years, and presented with jaundice and fatique.