Turkish Journal of Nephrology
Case Report

Rapidly Progressive Renal Failure and Multiple Primary Extranodal Involvement in a Patient with CD5 Positive Diffuse Large B Cell Lymphoma

1.

Ankara University Faculty of Medicine, Department of Nephrology, Ankara, Turkey

2.

Ankara University Faculty of Medicine, Department of Dermatology, Ankara, Turkey

3.

Ankara University Faculty of Medicine, Department of Pathology, Ankara, Turkey

Turkish J Nephrol 2018; 27: 104-107
DOI: 10.5262/tndt.2018.1001.11
Read: 1099 Downloads: 769 Published: 30 January 2019

CD5 positive diffuse large B cell lymphoma is a very rare subtype of diffuse large B cell lymphoma with an aggressive lymphoid neoplasm. Extranodal involvement of lymphoma usually appears secondarily in the setting of disseminated disease, but the disease may originate from various extralymphatic organs. We present a case of primary extranodal lymphoma with coexistence of skin and renal involvement with rapidly progressive renal failure due to lymhpomatous infiltration. Renal biopsy revealed diffuse infiltration of the renal parenchyma by CD20+ atypical lymphoid cells. The patient was treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone. After the chemotherapy regimen, a dramatic improvement in the clinical picture was noticed.

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