Turkish Journal of Nephrology
Case Report

Polyneuropathy, Myopathy and Hepatitis in a Child with Nephrotic Syndrome

1.

Karadeniz Technical University, Faculty of Medicine, Department of Pediatrics, Trabzon, Turkey

2.

Karadeniz Technical University, Faculty of Medicine, Department of Pathology, Trabzon, Turkey

3.

Karadeniz Technical University, Faculty of Medicine, Department of Neurology, Trabzon, Turkey

Turkish J Nephrol 2016; 25: 309-312
DOI: 10.5262/tndt.2016.1003.16
Read: 1204 Downloads: 732 Published: 08 February 2019

Acute sensorimotor polyneuropathy that resembles Guillain-Barre syndrome (GBS) and hepatitis is rarely accompanied with nephrotic syndrome. Its underlying immunological mechanisms are unclear. Involvement of immunological processes against common antigens in the glomerulus, peripheral nervous system and liver has been suggested. We describe a 5-year-old boy patient with acute sensorimotor polyneuropathy, myopathy and hepatitis that was accompanied with nephrotic syndrome. Renal biopsy showed membranoproliferative glomerulonephritis (MPGN). He was in remission on nephrotic syndrome and polyneuropathy at his 6-month follow-up. Approximately 40 cases have been reported in the literature and to our knowledge he is the first patient with these four conditions. In conclusion, this case report suggests that the same underlying immunological mechanisms appear in relation with each other. 

Files
EISSN 2667-4440