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Plasma carnitine levels and the effect of oral Lcarnitine supplementation on trigliceride and free faty acid levels were investigated in twenty uremic children on peritoneal dialysis.
No difference was found between patients and controls groups in respect to plasma total carnitine levels. However free carnitine levels were found to be low while acyl carnitine levels were high than that controls. Consequently acyl carnitine/free carnitine balance was disturbed in patients.
L-carnitine supplemantation at 50 mg/kg/day in patients, for one month, led to a significant increase ir total carnitine, free carnitine and acyl carnitine levels, •when compared with the previous levels but no significant change was observed in acyl carnitine/free carnitine balance. L-carnitine supplementation had also no effect on triglyceride and free faty acid levels.