Turkish Journal of Nephrology
Original Article

Osteoporosis and Associated Factors in Renal Transplant Patients

1.

Department of Internal Medicine, Division of Nephrology Ordu University Faculty of Medicine, Ordu, Turkey

2.

Anesthesiology and Reanimation Ordu University School of Medicine, Ordu, Turkey

3.

D-MED Dialysis Center Private Sector, Samsun, Turkey

4.

Biostatistics and Medical Informatics Ordu University Faculty of Medicine, Ordu, Turkey

Turkish J Nephrol 2022; 31: 66-73
DOI: 10.5152/turkjnephrol.2022.21066
Read: 1148 Downloads: 635 Published: 09 November 2021

Objective: The study aims to draw attention to the bone disease that occurs in the post-transplantation period in renal transplant patients, to investigate the factors that facilitate the formation of bone disease, and to assess the problems that may be associated with bone disease.

Methods: In addition to routine biochemical parameters, hormone tests and bone mineral density were measured in 85 patients who underwent renal transplantation. Total steroid dose (milligrams) of all patients until the dual-energy X-ray absorptiometry measurement was calculated. The patients were divided into 3 groups as normal, osteopenia, and osteoporosis according to the T score based on World Health Organization criteria.

Results: The mean age of the patients was 47.29 ± 13.32 years, and 59 (69.4%) patients were male. Transplantation time (Tx time) was statistically significantly higher in osteoporosis patients than in both the normal bone mineral density and osteopenia groups (P = .020). The mean total steroid dose of the patients in the osteoporosis group was higher than the patients in the normal bone mineral density group (P = .044). But when transplantation time (Tx time) was used as a covariate variable in analysis of variance, this difference among the bone mineral density groups was not statistically significant (P = .238). Alkaline phosphatase was statistically significantly higher in osteoporosis patients (P = .016). The 25-hydroxy vitamin D level of the patients in the osteoporosis group was statistically lower than in the normal bone mineral density group (P = .029).

Conclusion: Low 25-hydroxy vitamin D level, high alkaline phosphatase, and menopause are the risk factors for osteoporosis in renal transplant patients.

Cite this article as: Karataş A, Çanakçı E, Erdem E, Kasko Arıcı Y, Kaya M. Osteoporosis and associated factors in renal transplant patients. Turk J Nephrol. 2022;31(1):66-73.

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