Turkish Journal of Nephrology
Original Article

Kidney Transplantation in Patients Recovered from Coronavirus Disease 2019

1.

Department of Nephrology, İstanbul University, İstanbul School of Medicine, İstanbul, Türkiye

2.

Department of Nephrology, Ankara University School of Medicine, Ankara, Türkiye

3.

Organ Transplantation Center, Koç University Hospital, İstanbul, Türkiye

4.

Department of Nephrology, İstanbul Memorial Hizmet Hospital, İstanbul, Türkiye

5.

Department of Clinical Microbiology, Koç University Hospital, İstanbul, Türkiye

6.

Department of Infectious Disease and Clinical Microbiology, Ankara University School of Medicine, Ankara, Türkiye

Turkish J Nephrol 2023; 32: 228-234
DOI: 10.5152/turkjnephrol.2023.2295380
Read: 485 Downloads: 237 Published: 01 July 2023

Objective: There is limited information about kidney transplant recipients who recovered from the Coronavirus disease 2019. This study is conducted to investigate the safety of transplantation in this patient population.

Methods: Nineteen patients with prior coronavirus disease 2019 were included. We present demographics, clinical char- acteristics, laboratory findings, and immunosuppressive regimen. Graft functions and patient and allograft outcomes were compared to 19 kidney transplant recipients who did not have coronavirus disease 2019.

Results: The median age of participants was 38 (interquartile range, 26-51) years. Most of the recipients were men (n = 30, 78.9%). The most common presenting symptoms of kidney transplant recipients with prior coronavirus disease 2019 were fever (36.8%), fatigue (21.1%), dyspnea (15.8%), cough (10.5%), and myalgia (5.3%). Eight patients (42.2%) were hospital- ized, while none required intensive care unit admission and mechanical ventilation. The median wait time for transplan- tation after the initial diagnosis of coronavirus disease 2019 was 82 days (interquartile range, 57-172). Most recipients in both groups received antithymocyte globulin as an induction agent. Standard doses of maintenance immunosuppression consisting of tacrolimus, mycophenolate derivatives, and corticosteroids were administered. During a follow-up duration of 85 (interquartile range, 39-154) and 134 (interquartile range, 56-240) days for patients and controls, respectively, the rate of complications and graft functions were not statistically significant between groups. Graft and patient survival was 100%.

Conclusion: Our study results support the safety of kidney transplantation in patients with prior coronavirus disease 2019. Transplant candidates and donors should be carefully screened for coronavirus disease 2019. We suggest continuing the standard doses of induction and maintenance immunosuppression, especially in patients who recovered without pulmo- nary sequelae.

Cite this article as: Artan AS, Eren Sadioğlu R, Yelken B, et al. Kidney transplantation in patients recovered from coronavirus disease 2019. Turk J Nephrol. 2023;32(3):228-234.

Files
EISSN 2667-4440