Kaposi sarcoma (KS) is a neoplasm characterized by abnormal angiogenesis that can present with cutaneous lesions. It requires infection with Human Herpes Virus 8 (HHV-8) and is associated with a dysfunctional immune system. Here, we report the case of KS in a patient who underwent hemodialysis (HD) to treat chronic renal failure (CRF). This case is another example of CRF- and HD-associated immunologic dysregulation possibly resulting in the development of KS due to activation of HHV-8.