Immune Tolerance in Transplant Kidney

Immune tolerance in transplantation is the successful preservation of the allograft throughout the recipient’s lifetime. Cases with immunotolerance are of great importance in understanding the immune tolerance process and for possible innovations in the diagnosis and treatment processes. We aimed to present a patient who underwent renal transplantation from a cadaveric donor and revealed  immunosuppressive withdrawal after two years of the transplantation. Cadaveric renal transplantation was performed on the 65-year-old patient after an 18-hour cold ischemia period. A 3/6 haplotype match and negative panel reactive antibody results were detected for both class I and class II antigens. The patient was discharged on post-operative day 13. Non-compliance was detected in the post-operative 29th month, and a renal biopsy was performed in the 56th month. Histological findings were nonspecific. The patient still lives with normal allograft functions. The absence of a clinical rejection in the follow-up of our case, which cannot be counted in the low-risk group in terms of rejection, reveals the importance of immune tolerance in maintaining allograft functions.

Cite this article as: Bozacı İ, Tatar E, Uslu A, Taşlı F. Renal Transplant Immune Tolerance. Turk J Nephrol 2021; 30(1): 86-9.v