Turkish Journal of Nephrology
Original Articles

Economic Benefit of Anti-PLA2R Antibody Testing in the Diagnosis of Membranous Nephropathy: A Single-Center Cost Analysis

1.

Division of Nephrology, Gazi University Faculty of Medicine, Ankara, Türkiye

2.

Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Türkiye

3.

Divisionof Nephrology, Sincan Training and Research Hospital, Ankara, Türkiye

4.

Department of Nephrology, Etlik City Hospital, Ankara, Türkiye

5.

Department of Medical Biochemistry, Gazi University Faculty of Medicine, Ankara, Türkiye

6.

Department of Pathology, Gazi University Faculty of Medicine, Ankara, Türkiye

Turkish J Nephrol 2025; 34: 267-271
DOI: 10.5152/turkjnephrol.2025.251103
Read: 95 Downloads: 45 Published: 01 October 2025

Background: This study aimed to evaluate the financial impact of using anti-phospholipase A2 receptor antibody testing instead of kidney biopsy for diagnosing membranous nephropathy.

Methods: A retrospective cross-sectional study was conducted at Gazi University Faculty of Medicine Hospital between November 2022 and January 2024. Seventy adult patients with nephrotic syndrome underwent anti-phospholipase A2 receptor antibody testing using an enzyme-linked immunosorbent assay. The costs of diagnosis based on serology and kidney biopsy were compared.

Results: Among 70 patients, 18 tested positive for anti-phospholipase A2 receptor antibodies. Of these, 13 were diagnosed without a kidney biopsy, leading to a cost reduction of approximately 52 000 Turkish Liras (1300 American Dollars). The total expense for anti-phospholipase A2 receptor antibody testing was significantly lower than that of kidney biopsy, which required hospitalization and procedural costs. If all antibody-positive patients had been diagnosed without a biopsy, the potential savings would have reached 24 000 Turkish Liras (600 American Dollars).

Conclusion: Anti-phospholipase A2 receptor antibody testing provides a cost-effective, non-invasive alternative to kidney biopsy for diagnosing membranous nephropathy. Implementing a serology-first approach in selected cases may significantly reduce healthcare expenditures while maintaining diagnostic accuracy.

Cite this article as: Demirezen A, Malkoç NA, Akçay ÖF, et al. Economic benefit of anti-PLA2R antibody testing in the diagnosis of membranous nephropathy: A single-center cost analysis. Turk J Nephrol. 2025;34(4):267-271.

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