Turkish Journal of Nephrology
Original Article

Continuous Erythropoietin Receptor Activator Ameliorates Diabetic Kidney Disease in Rats

1.

Department of Physiology, Alanya Alaaddin Keykubat University School of Medicine, Antalya, Turkey

2.

Department of Nephrology, Alanya Alaaddin Keykubat University School of Medicine, Antalya, Turkey

3.

Department of Nephrology, Bahçeşehir University Hospital Medical Park Göztepe, İstanbul, Turkey

Turkish J Nephrol 2020; 29: 264-272
DOI: 10.5152/turkjnephrol.2020.3958
Read: 243 Downloads: 72 Published: 20 October 2020

Objective: Diabetic kidney disease (DKD) is still a significant cause of morbidity in patients with diabetes. In this study, we examined the potential effects of continuous erythropoietin receptor activator (CERA) on oxidative stress, inflammation, and the renin-angiotensin system in a rat model of DKD induced by streptozocin.

Materials and Methods: A single intraperitoneal injection of streptozocin (65 mg/kg) was used in male Sprague Dawley rats to induce diabetes. The rats were randomly divided into 4 groups (n=8/group): diabetic (group D), CERA (group CR), CERA-treated diabetic group (group D+CR), and the control group (group C). The oxidative stress biomarkers, renal function parameters, messenger-ribonucleic acid expression of renin-angiotensin system parameters, and kidney histology were investigated.

Results: Creatinine clearance was found to be increased and the urinary albumin-to-creatinine ratio decreased in group D+CR compared with that of group D. Serum malondialdehyde levels were significantly lower, and glutathione and glutathione peroxidase levels were significantly higher in group D+CR than those of group D. Serum interleukin-1β, tumor necrosis factor-α, and interferon-γ levels were significantly lower; and monocyte chemoaatractant protein 1 levels were significantly higher in group D+CR than those in group D.

Conclusion: CERA can protect against DKD, in part, and is related to the suppression of the renal oxidative and inflammatory response.

Cite this article as: Günal MY, Eren Z, Arı Bakır E. Continuous Erythropoietin Receptor Activator Ameliorates Diabetic Kidney Disease in Rats. Turk J Nephrol 2020; 29(4): 264-72.

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