Turkish Journal of Nephrology

What does an Elevated N-terminal Pro-brain Natriuretic Peptide (NT-pro-BNP) Mean in my Renal Patient?


Department of Clinical Science, Intervention and Technology; Karolinska Institutet, Stockholm, Sweden

Turkish J Nephrol 2010; 19: 77-81
DOI: 10.5262/tndt.2010.1002.01
Read: 343 Downloads: 185 Published: 12 February 2019

The N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is released in response to volume expansion and/or increased tension on cardiac ventricular myocytes. In non-uremic patients, NT-pro-BNP is a useful diagnostic and prognostic biomarker for diagnosis and risk assessment of patients with heart failure. However, impaired kidney function is associated with elevated circulating levels of NT-proBNP. The present review summarizes the literature on NT-pro-BNP in kidney disease, both acute and chronic. We attempt to highlight the importance of estimating kidney function before interpreting an elevated NT-pro-BNP measurement. We also suggest that NT-pro-BNP is not a reliable marker of heart failure in the acute setting, but that longitudinal changes may be of value when tracking volume status in this patient group. 

EISSN 2667-4440