Turkish Journal of Nephrology
Review

Uremic Pruritus: Still Itching

1.

Marmara University Faculty of Medicine, Department of Internal Medicine, Department of Nephrology, Istanbul, Turkey

Turkish J Nephrol 2011; 20: 7-13
DOI: 10.5262/tndt.2011.1001.02
Keywords : Uremia, Itch, Hemodialysis
Read: 1569 Downloads: 943 Published: 06 February 2019

Uremic pruritus is a common complication of chronic renal failure. It affects 50% of patients undergoing hemodialysis or peritoneal dialysis. The causes of pruritus in uremic patients are still unknown. Xerosis, intradermal microprecipitation of divalent ions, secondary hyperparathyroidism, peripheral neuropathy, allergic reactions, hypersensitivity and histamine have been considered as pathogenetic factors. The cornerstone of therapy for uremic pruritus is regular, intensive, efficient dialysis. Other therapeutic measures include topical emollients, topical capsaicin, systemic antihistaminics, gabapentine and phototherapy.

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