Acetylsalicylic acid (ASA) is a member of the non-steroidal anti-inflammatory drugs (NSAIDs). Thus, it can cause side effects such as fluid, electrolyte and acid-base imbalances through the enzyme cyclooxygenases (COX 1-2). Despite the wide use of ASA and its general good safety profile, sensitivity to ASA should be kept in mind. Here, we reported a patient who presented with hypertension and hyperkalemia after low dose ASA treatment.