Trends in Acute Renal Failure in Central Anatolia

OBJECTIVE: Our main purpose was to evaluate the epidemiological properties and mortality rate of this study and to evaluate the etiology and factors associated with mortality in patients with ARF.

MATERIAL and METHODS: In this prospective observational study a total of 541 patients with ARF were assessed between January 2008 - January 2012. The etiological spectrum and predictors of mortality were evaluated in this population.

RESULTS: The mean age was 64.9 ± 15.6 years and the majority of patients were male. The most common etiology of ARF was medical causes. Diarrheal disease and drug-induced ARF were the major medical causes. One hundred and fi fty four patients needed dialysis. The most common cause of death was cardiopulmonary failure. In multivariate analysis, dialysis necessity, age, C-reactive protein, serum sodium, serum phosphorus, serum albumin, and hemoglobin were independently associated with death after adjusting for other variables.

CONCLUSION: ARF resulting from medical diseases was higher compared to surgical causes. Use of medication with antibiotics and non-steroid anti-infl ammatory drugs was predominantly increased; however the main cause was diarrheal disease. Hypoalbuminemia, anemia, dialysis requirement and hyperphosphatemia were found to be the main predictors of mortality in patients with ARF.