Thiol/Disulphide Homeostasis in Autosomal Dominant Polycystic Kidney Disease: A Single Center, Cross-Sectional Study

OBJECTIVE: The aim of this study was to determine a novel oxidative stress marker, plasma thioldisulphide homoeostasis, in patients with autosomal dominant polycystic kidney disease (APKD).

MATERIAL and METHODS: Thirty-four patients with autosomal dominant polycystic kidney disease and 30 healthy volunteers were included in the study. The thiol-disulfide homeostasis assay was performed. Total antioxidant capacity was evaluated via the FRAP assay.

RESULTS: The median age was 46 (13) years in the patient group and 41 (13) years in the control group. In the APKD disease group, serum total and native thiol levels were statistically significantly lower (p = 0.002, p = 0.002, respectively). Serum native thiol levels were negatively correlated with age (r:-0.620 p: 0,000), systolic blood pressure (r: -0,697 p: 0,000), and diastolic blood pressure (r: -0,643 p: 0,000). A weak positive correlation was found between the disulfide/native thiol ratio and creatinine (r: 0.564 p <0.001), and a negative correlation was found between the disulfide/native thiol ratio and glomerular filtration rate (r: -0.372 p: 0.030). There was a significant positive correlation between the native thiol level and GFR (r: 0.699, p <0.001) level.

CONCLUSION: Our findings suggest that thiol/disulfide homeostasis may be associated with autosomal dominant polycystic kidney disease progression.