The Utility of Bone Morphogenetic Protein 7 Levels on Predicting the Alteration of the Peritoneal Membrane Permeability

Background: This study aimed to investigate the potential relationship between bone morphogenetic protein 7 (BMP-7) and peritoneal permeability, as well as clinical outcomes.

Methods: We conducted a cross-sectional study involving 67 peritoneal dialysis (PD) patients who had been on PD for at least 1 year. We measured BMP-7 levels in both plasma and PD effluent fluid. Two peritoneal equilibration tests, the first and last ones, were compared to assess alterations in peritoneal membrane permeability. Dialysate to plasma ratio for creatinine (DPRC) was used to define membrane permeability. BMP-7 level was measured concurrently in both plasma and PD effluent.

Results: Among the patients, 81% (n = 51) were on ambulatory PD, while 19% (n = 12) were on automated PD. The average PD duration was 58.9 months. Increased DPRC was determined in 61.9% of the patients. There was a positive correlation between plasma BMP-7 levels and the change in DPRC (r = 0.323, P = .004). No correlation was determined between effluent BMP-7 levels and changes in DPRC. A statistically significant negative correlation was determined between plasma BMP-7 levels and serum albumin levels (r = −0.274, P = .02). Plasma BMP-7 levels independently predicted changes in DPRC (P = .02), while effluent BMP-7 levels did not (P = .212).

Conclusion: We identified a correlation between plasma BMP-7 level and changes in peritoneal membrane permeability. However, we did not find any relationship with the PD clinical outcomes. Plasma BMP-7 levels can serve as a parameter for predicting alterations in permeability.

Cite this article as: Uysal C, Gundogdu A, Koyuncu S, Kocer D, Ipekten F, Kocyigit I. The utility of bone morphogenetic protein 7 levels on predicting the alteration of the peritoneal membrane permeability. Turk J Nephrol. 2024;33(3):295-300.