The Relationship Between Parathyroid Hormone, Insulin Resistance and Blood Pressure in Newly Diagnosed Hypertensive Patients with Various Levels of Kidney Function

OBJECTIVE: There are scarce data regarding the relationship between insulin resistance, parathyroid hormone (PTH) and blood pressure (BP) in the literature. This study is aimed to investigate the interrelationships between BPs, insulin resistance and PTH levels in never treated newly diagnosed essential hypertensive patients.

MATERIAL and METHODS: All patients underwent history taking, physical examination, BP measurement, 12 lead electocardiographic evaluations, routine urine analysis, biochemical analysis and 24-hour urine collection to measure protein excretion and creatinine clearance. Insulin resistance was calculated by homeostasis model assessment (HOMA) index.

RESULTS: In total 92 patients were included. Spearman correlation analysis revealed that systolic BP was correlated with diastolic BP (rho: 0.337, p: 0.001), with age (rho: 0.214, p: 0.041) with body mass index (rho: 0.325, p: 0.004), with blood urea nitrogen (rho: 0.262, p: 0.012), with HOMA-INDEX (rho: 0.273, p: 0.009) and with insulin levels (rho: 0.262, p: 0.012). There was no correlation between PTH and systolic BP. Spearman correlation analysis revealed that diastolic BP was correlated with fasting blood glucose (rho: 0.220, p: 0.035), and PTH levels (rho: 0.235, p: 0.024).

CONCLUSION: In conclusion, we suggest that although PTH and HOMA-INDEX are related with BPs, discrepancy exists regarding systolic and diastolic BPs.