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Objective: The dietary total antioxidant capacity (dTAC) is the cumulative total of all antioxidant compounds contained in food and is associated with dietary food consumption. Therefore, it can be used as an indicator of dietary quality. The aim of the study is to assess the relationship between dTAC values with serum antioxidant (total antioxidant capacity (TAC); paraoxonase1 (PON1), and arylesterase (ARES)) and oxidant (total oxidant status (TOS); Oxidative Stress Index (OSI), and malondialdehyde (MDA)) parameters in hemodialysis patients.
Methods: This experimental randomized controlled human study was conducted in 2 dialysis centers in Bingol, Turkey. In this study, 46 participants were included in each of the 2 groups of hemodialysis and control. The dietary intake was assessed with a 7-day food diary, and the dTAC values were calculated from databases of oxygen radical absorbance capacity (ORAC), ferric reducing antioxidant power (FRAP), total radical-trapping antioxidant parameter (TRAP), trolox equivalent antioxidant capacity (TEAC), and the equation of vitamin C equivalent antioxidant capacity (VCEAC).
Results: The values of dTAC were lower in the hemodialysis patients than in the control group (P < .01). There was a positive correlation between the values of TEAC, TRAP, FRAP, and serum PON1, whereas there was a significant negative correlation between C-reactive protein (CRP) values (P < .05).
Conclusion: The dietary TAC values were lower in the hemodialysis patients, and they were related with serum PON1 and CRP. Increasing the dTAC content is thought to have positive effects on patients, and it should be increased by providing healthy nutrition.
Cite this article as: Özkalaycı RE, Çoban Ş, Rakıcıoğlu N. The relationship between dietary total antioxidant capacity with serum antioxidant and oxidant parameters in hemodialysis patients. TurkJ Nephrol. 2021; 30(4): 300-307.