The Mutation Identified in TWEAK-Fn14 Pathway May Affect the Clinical Course of IgA Nephropathy/Henoch- Schönlein Purpura Nephritis: A Case Report

The TNF-like weak inducer of apoptosis (TWEAK) gene was first discovered in 1997 and its receptor Fn14 in 2001. TWEAK can be protective or damaging, depending on the status of the tissue. While basal TWEAK and Fn14 concentrations were found to be low in the kidney under normal conditions, TWEAK levels and tissue receptor expression were found to be increased in the presence of an acute injury.We report here the first case with persistent microscopic hematuria since infancy with TWEAK gene mutation, who was diagnosed with IgA Nephropathy/Henoch-Schönlein Purpura Nephritis at the age of 18 during a kidney biopsy. The genetic mutation in this patient may have caused a better course of the disease.

Cite this article as: Kendi Çelebi Z, Turgut D, Erdoğmuş Ş, Avşaroğlu E, Muşabak HU, Çolak T. The mutation identified in tweak-Fn14 pathway may affect the clinical course of IgA nephropathy/Henoch-Schönlein purpura nephritis: A case report. Turk J Nephrol. 2021; 30(3): 250-252.