Turkish Journal of Nephrology
Review

The Frailty of Advanced Kidney Disease: The Role of Mitochondria

1.

Division of Nephrology, Uludağ University, Faculty of Medicine Bursa, Türkiye

2.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

3.

Veterans Health Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA

Turkish J Nephrol 2022; 31: 190-193
DOI: 10.5152/turkjnephrol.2022.22317
Read: 311 Downloads: 86 Published: 01 July 2022

Uremic toxins contribute to the impairment of mitochondrial function that subsequently could result in organ failure. Mitochondrial dysfunction also plays an essential role in the pathogenesis of sarcopenia in chronic kidney disease patients. It may be feasible to assess the effect of mitoc hondr ial-t arget ed drugs to treat sarcopenia in patients with chronic kidney disease.

Cite this article as: Yıldız A, İkizler TA. The frailty of advanced kidney disease: The role of mitochondria. Turk J Nephrol. 2022;31(3):190-193.

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