The Effect of Zofenopril on Pancreas, Kidney and Liver of Diabetic Rats

OBJECTIVE: Oxidative stress is responsible for some important complications of diabetes mellitus. Zofenopril, which has an antioxidant effect, may decrease the oxidative stress of the diabetic microenvironment. The aim of our study was to evaluate the effect of zofenopril in the liver, pancreas and kidney of alloxan-induced diabetic rats.

MATERIAL and METHODS: Rats were divided into five groups: control group (n=6), rats treated with zonenopril (50 mg/kg/day, orally four weeks; n=6), rats exposed to alloxane (120 mg/kg single dose intraperitoneal injection, n=6), rats administered alloxan+zofenopril (n=6) and rats administered insulin plus alloxan.

RESULTS: After one month, we observed histological improvement in the kidneys but not in the pancreas and liver.

CONCLUSION: In conclusion, zofenopril may be effective on the renal complications of diabetes mellitus.