Turkish Journal of Nephrology
Original Article

The Effect of Ultrapure Dialysate on Clinical Outcomes and Mortality During One Year Follow-up in Patients Undergoing Hemodialysis Treatment

1.

Department of Nephrology, Hitit University School of Medicine, Çorum, Turkey

2.

Department of Hemodialysis, Hitit University School of Medicine, Çorum, Turkey

3.

Department of Medical Biochemistry, Hitit University School of Medicine, Çorum, Turkey

Turkish J Nephrol 2020; 29: 205-211
DOI: 10.5152/turkjnephrol.2020.3979
Read: 70 Downloads: 28 Published: 23 June 2020

Objective: We investigated the relationship between mortality and clinical status in patients with hemodialysis using ultrapure dialysate and standard dialysate.

Materials and Methods: The study included 81 patients using ultrapure dialysate (Group 1) and 72 patients using standard dialysate (Group 2). Mortality rates, anemia, phosphorus, albumin, parathormone, and C-reactive protein (CRP) values were calculated as 1-year averages. Factors affecting mortality were evaluated by logistic regression analysis.

Results: In Group 1, potassium, phosphorus, uric acid, CRP, and hemoglobin levels were significantly higher (p<0.001, p=0.023, p=0.010, p=0.003, p<0.001, respectively), and transferrin saturation, ferritin, and HCO3− levels were significantly lower (p=0.007, p<0.001, p=0.001, respectively) than Group 2. The erythropoietin-stimulating agent’s usage dose of Group 1 was 0.60 (0.11-1.00) μg/kg/month and 1.30 (0.80-2.17) μg/kg/month in Group 2 (p<0.001). Iron usage doses of Group 1 and Group 2 were 800 (425-1,275) mg/year and 1,300 (750-2,000) mg/year, respectively (p=0.002). There was no significant difference in mortality rates for the 1-year follow-up period (mortality rate in 12 patients [14.8%] in Group 1, 6 patients in Group 2 [8.9%], p=0.214). In the univariate and multivariate logistic regression analyses, age, serum Na, total protein, and CRP levels were found to be independent variables to determine mortality.

Conclusion: After 1 year of short-term follow-up, Group 1 had better anemia control than Group 2 but no positive effect on mortality.

Cite this article as: Doğan İ, Ünal Kaya N, Kayadibi H. The Effect of Ultrapure Dialysate on Clinical Outcomes and Mortality During One Year Follow-up in Patients Undergoing Hemodialysis Treatment. Turk J Nephrol 2020; 29(3): 205-11.

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