Turkish Journal of Nephrology
Original Article

The Association Between Progression of Carotid Artery Intima-Media Thickness and Cardiovascular Events in Peritoneal Dialysis Patients

1.

Ege University Faculty of Medicine, Department of Nephrology, Izmir, Turkey

2.

Ege University Faculty of Medicine, Department of Radiology, Izmir, Turkey

Turkish J Nephrol 2013; 22: 238-244
DOI: 10.5262/tndt.2013.1003.02
Read: 816 Downloads: 428 Published: 06 February 2019

OBJECTIVE: Measurement of carotid artery intima-media thickness (CA-IMT) is directly associated with cardiovascular (CV) outcomes. We retrospectively investigated the impact of CA-IMT progression on new CV events in patients on peritoneal dialysis (PD).

MATERIAL and METHODS: All PD patients who have been followed in our unit (n=163) were screened. The patients who had no CA-IMT were excluded. Ninety-six patients who had baseline CAIMT measurement were included. Fifty-two patients had second CA-IMT measurement. Fatal and nonfatal CV events were screened from patients’ charts.

RESULTS: At baseline, mean CA-IMT was 0.62±0.16 mm (median 0.60 mm). In patients treated with PD more than 2 years, CV event rate was higher in patients with high CA-IMT (>0.60 mm) compared to the patients with low CA-IMT at baseline (22.2% versus 4.2%, p=0.041). In patients who had second CA-IMT measurement, mean CA-IMT increased from 0.62±0.17 mm to 0.66±0.17 mm (p=0.002). In ROC analysis, best cut-off value of CA-IMT progression was 0.0062 mm/month for prediction of CV events (AUC 0.752±0.066, p=0.046). When patients were grouped according to this cut-off value, CV event rate was higher in patients showed CA-IMT progression above 0.0062 mm/month (33.3% versus 2.7%, p=0.001). In Cox-regression analysis, progression of CA-IMT more than 0.0062 mm/month was only predictor for new CV events (ExpB=14.57, p=0.015).

CONCLUSION: Consecutive assessment of atherosclerosis progression by CA-IMT measurement has importance for prediction of new CV events in PD patients.

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EISSN 2667-4440