Turkish Journal of Nephrology
Original Article

Serum Parathyroid Hormone Levels and All-Cause Mortality Risk in Hemodialysis Patients in the Black Sea Region of Türkiye

1.

Dmed Samsun Dialysis Clinic, Samsun, Türkiye

2.

Department of Nephrology, Demiroğlu Bilim University, Faculty of Medicine, İstanbul, Türkiye

Turkish J Nephrol 2024; 33: 53-58
DOI: 10.5152/turkjnephrol.2023.22398
Read: 145 Downloads: 87 Published: 05 January 2024

Objective: The association between serum parathyroid hormone levels and the all-cause mortality risk in patients with chronic kidney disease grade 5 treated by hemodialysis was examined.

Methods: A total of 408 hemodialysis patients living in the Black Sea region of Türkiye were included in this study. Cox proportional hazards regression analysis was performed.

Results: The median age of patients was 64 (57-71) years. The median follow-up duration was 51 (28-60) months. During follow-up, 205 (50.2%) patients died. In the multivariable-adjusted analysis, the time-averaged serum parathyroid hormone level of 450-599 pg/mL had the lowest mortality risk. The all-cause mortality risk was elevated in patients with timeaveraged parathyroid hormone― levels of <150 and ≥600 pg/mL. Patients with a time-averaged corrected serum calcium level of ≥9.5 mg/dL and a time-averaged serum phosphorus level of <4.0 mg/dL also had increased all-cause mortality risk.

Conclusion: The all-cause mortality risk was increased in hemodialysis patients with time-averaged parathyroid hormone levels of <150 and ≥600 pg/mL. Hypercalcemia and hypophosphatemia also increased the all-cause mortality risk.

Cite this article as: Erdem E, Tevfik Ecder S. Serum parathyroid hormone levels and all-cause mortality risk in hemodialysis patients in the black sea region of Türkiye. Turk J Nephrol. 2024;33(1):53-58.

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