Risk Factors of Delayed Graft Function in Transplantation of Mate Kidneys

Objective: The goal of this study was to identify risk factors among donor characteristics that affect delayed graft function (DGF) in paired kidney transplants.

Materials and Methods: A retrospective analysis of 35 paired kidney transplants, which were performed between 1993 and 2017 was conducted. Risk factors for DGF were determined using logistic regression analysis.

Results: In univariate analysis, cold ischemia time, donor age, anti-timocyte globulin use, donor serum creatinine, and DGF in the mate kidney were significantly associated with DGF development. In the multivariate regression model, cold ischemia time (OR 1.21; 95% 1.02-1.44, p=0.029) and DGF in the mate kidney (OR 13.65, 95% 3.42-54.42, p<0.001) were independent predictors of DGF in the recipient. In patients with DGF, renal functions are negatively affected, calcineurin toxicity development is facilitated, and allograft loss is increased. 

Conclusion: There is a significant degree of relationship between pairs of kidneys transplanted from the same donor for the occurence of DGF. In patients with allograft dysfunction, assessment of the function of the mate kidney and comparison with that of the recipient is essential. 

Cite this article as: Oktan MA, Heybeli C, Derici ZS, Ünlü M, Arda HÜ, Uzun Ö, et al. Risk Factors of Delayed Graft Function in Transplantation of Mate Kidneys. Turk J Nephrol 2020; 29(2): 108-14.