Retrospective Analysis of the Cases Diagnosed With Rapidly Progressive Glomerulonephitis

AIM: In the present study, we investigated clinical and histopathological findings, treatment, and course of patients with crescentic glomerulonephritis in our center.

PATIENTS and METHODS: 35 patients who were diagnosed with crescentic glomerulonephritis by renal biopsy were retrospectively investigated.

RESULTS: 25 (71.4%) of the patients were male and mean age was 34.43 ± 15.7 years. All of 13 patients had serum creatinine level ≥ 5 mg/dl and 7 of 18 patients who had serum creatinine level < 5 mg/dl did not respond to treatment and developed end stage renal disease (ESRD). The crescentic glomerular change percentage was significantly higher in patients who did not respond to treatment and developed ESRD than those who respond to treatment (79.04 ± 21.57 vs. 52.21 ± 20.63, p = 0.002). There was a significant positive correlation between the crescentic glomerular change percentage and serum creatinine level.

CONCLUSION: In crescentic glomerulonephritis, there is a significant correlation between histopathological findings and renal function. In patients who have severe renal failure (serum creatinine level ≥5 mg/dl) at diagnosis, prognosis of crescentic glomerulonephritis is poor and the development of ESRD is common, although treatment is given.