Pseudotumor cerebri (PTC) is a syndrome with increased intracranial pressure (>200 mmH2O) and characterized by headache, loss of vision and papiledema. Many drugs and diseases may lead to this clinical picture and Cyclosporin A is one of them. A 17-year-old case with PTC who had undergone cadaveric renal transplantation due to chronic renal failure secondary to reflux nephropathy after six months' duration of hemodialysis program and who was on CyA, azathioprine and steroid as immune suppressants for 3 years after transplantation is reported hereby. It should be kept in mind that the patients who undergo renal transplantation and who are on treatment modalities including CyA are at risk of PTC and delay of prompt treatment may lead to blindness.