Overview of Nonspecific and Innovative Therapies with the Potential to Reduce Chronic Kidney Disease Progression

Management of chronic kidney disease has always been challenged by the need for therapies or interventions that prolong time to dialysis. Given the high global incidence and prevalence of chronic kidney disease, the need for cost-effective and patient-centered interventions, aiming to postpone dialysis initiation, becomes crucial. Longevity increase and prolongation of dialysis-free interval would mean improvement in quality of life for millions of people and their families worldwide. It also decreases pressure on the health system. In the last years, the efforts of the scientific community on this matter have been rewarded by the excellent results of sodium-glucose 2-co-transport inhibitors and selective aldosterone blockers on chronic kidney disease progression, and these innovations merit to be considered milestones in nephrology. Several non-specific therapies for chronic kidney disease, such as antif ibrot ic/an ti-in flamm atory , and anti-diabetic therapies targeting cellular metabolism and beyond, have an effect on the progression of chronic kidney disease. This review discusses in a comprehensive way these therapies on the view of the potential for decrease of chronic kidney disease progression.

Cite this article as: Spahia N, Rroji M, Idrizi A, Barbullushi M. Overview of nonspecific and innovative therapies with the potential to reduce chronic kidney disease progression. Turk J Nephrol. 2022;31(4):269-278.