We report a case of epididymal calcification that was diagnosed sonographically in a hemodialysis patient. Epididymal head calcification was an incidental finding in an infertile 28-year-old man undergoing scrotal sonographic examination to investigate infertility. The testes had normal appearance. Semen parameters were abnormal which included oligospermia (few spermatozoa in semen), and asthenospermia (reduced sperm motility). Here, we discussed microlithiasis of the epididymis related to hemodialysis or end-stage renal disease and accompanying the sperm abnormalities that caused infertility. Hemodialysis is one of the reasons of the epididymal calcification via abnormalities of the calcium/phosphate metabolism.