Metabolic Syndrome and Arterial Stiffness in Peritoneal Dialysis Patients

OBJECTIVE: The metabolic syndrome (MetS) is an endocrinopathy that increases the risk of cardiovascular disease. Arterial stiffness is commonly used to evaluate the risk of cardiovascular disease, which is quantified by pulse wave velocity (PWV) and augmentation index (AIx). Our study aim was evaluate the prevalence of MetS and arterial stiffness in peritoneal dialysis patients.

MATERIAL and METHODS: A total of 36 peritoneal dialysis patients were included. Patients’ waist circumference, body mass index (BMI), blood pressure, glucose, triglyceride, and HDL-cholesterol levels were recorded. PWV and AIx measurements were performed by means of the Mobil-O-Graph device. Adult Treatment Panel III criteria were used for the diagnosis of MetS.

RESULTS: 47.2% of peritoneal dialysis patients had MetS, and the prevalence of MetS was found to be 61% above the age of 55 years. Patients with MetS had higher BMI, waist circumference, glucose, triglyceride levels. Median age was significantly higher in the MetS group (p=0.044). Ageadjusted analysis revealed significantly higher Alx@75 in the MetS group (p=0.025); but no significant difference was observed in PWV. In regression analysis, the age, central systolic blood pressure, and augmentation pressure appeared as the independent determinants of PWV.

CONCLUSION: Metabolic Syndrome prevalence was found to be 47.2%, and it was more common in subjects older than 55 years. In the MetS group, the Alx@75 values were found to be significantly higher.