Gastrointestinal system (GIS) manifestations are common in systemic lupus erythematosus (SLE) patients. The gastrointestinal vasculopathy of SLE is a unique clinical entity and reviewed infrequently but it should be kept in mind to give the necessary treatment with corticosteroids and other immunosuppressive agents and to avoid non-essential surgical interventions. Here we report a 33-yearold SLE patient that presented with surgical acute abdomen symptoms, was followed-up in a Nephrology Department, and was well managed with high doses of corticosteroids and cyclophosphamide after the diagnosis of GIS vasculopathy.