Turkish Journal of Nephrology
Original Article

Is Isolated Autoantibody Seropositivity a Risk Factor in the Development of Diabetic Nephropathy in Type 1 Diabetic Children?


Department of Pediatric Nephrology, Mustafa Kemal University School of Medicine, Hatay, Türkiye


Department of Pediatric Nephrology, Gaziantep University School of Medicine, Gaziantep, Türkiye


Department of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Türkiye


Department of Pediatric Nephrology, İzmir Tepecik Training and Research Hospital, İzmir, Türkiye


Department of Pediatric Endocrinology, Dicle University Scool of Medicine, Diyarbakır, Türkiye


Department of Pediatric Gastroenterology, Gazi Yaşargil Research and Training Hospital, Diyarbakır, Türkiye


Department of Pediatric Endocrinology, Gazi Yaşargil Research and Training Hospital, Diyarbakır, Türkiye

Turkish J Nephrol 2023; 32: 249-254
DOI: 10.5152/turkjnephrol.2023.2289378
Read: 455 Downloads: 288 Published: 01 July 2023

Objective: Diabetic nephropathy is one of the most important complications in diabetes mellitus. We aimed to examine the influence of organ-specific antibody seropositivity in diabetic nephropathy.

Methods: Patients with type 1 diabetes and no evidence of celiac disease, thyroid dysfunction, and other kidney diseases and with an annual average HbA1c level <10%, body mass index <25 kg/m2, and normal blood pressure were enrolled.

Results: Eighty patients (39 boys and 41 girls) were evaluated. Twenty patients with moderately increased albuminuria (diabetic nephropathy group) and 60 patients without albuminuria (control group) showed no statistical difference in age, gender, diabetes duration, age at diagnosis, kidney function tests, and mean blood pressure measurements. Compared to control group, the mean anti-thyroglobulin level and anti-thyroxin peroxidase level were statistically higher in the diabetic nephropathy group, P = .004 and P = .045, respectively. However, the thyroid function tests were normal in either group.

Conclusion: Determination of the impact of autoantibody seropositivity on the risk of diabetic nephropathy in type 1 dia- betic children could be a non-traditional marker in the risk assessment of diabetic nephropathy.

Cite this article as: Taktak A, Akbalık Kara M, Çiçek N, et al. Is isolated autoantibody seropositivity a risk factor in the development of diabetic nephropathy in type 1 diabetic children?. Turk J Nephrol. 2023;32(3):249-254.

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