Turkish Journal of Nephrology
Original Article

Investigating Effects of Hepatitis C Virus on Platelet Parameters in Hemodialysis Patients

1.

Gaziosmanpaşa Üniversitesi Tıp Fakültesi, İç Hastalıkları AD, Nefroloji BD, Tokat

2.

Yüzüncü Yıl Üniversitesi Tıp Fakültesi, İç Hastalıkları AD, Van

3.

Van Yüksek İhtisas Hastanesi Hemodiyaliz Ünitesi, Van

Turkish J Nephrol 2006; 15: 37-42
Read: 980 Downloads: 686 Published: 14 February 2019

AIM: In this study, we aimed to investigate the effects of hepatitis C virus on platelet parameters in hemodialysis patients.

MATERIALS and METHODS: We included patients who received hemodialysis in Van region in Turkey. Platelet counts, mean platelet volume (MPV), platelet distribution width and plateletcrit, antiHCV antibodies were measured. Relations between anti-HCV antibodies and platelet parameters were investigated.

RESULTS: We included a total of 142 patients, 76 anti-HCV antibodies positive (30 female, 46 male) and 66 negative (25 female, 41 male). Mean age was 42 ± 16 years in HCV (-) and 44 ± 13 in HCV (+) patients. There were no significant associations between age, gender in two groups. The ratio of thrombocytopenia was 43.6%. Platelet counts was 178 ± 73 000/mm3 in patients with anti-HCV positive and 219 ± 76 000/mm3 in anti-HCV negative. We found statistically significant differences between the two groups (p<0.0001). Moderate thrombocytopenia was seen in 14.7% in anti-HCV(+) patients group and 3% in anti-HCV negative patients. There were negative correlations between anti-HCV (+) and low-platelet counts (Pearson correlation coefficient, r= -0.261, p<0.001). Mean platelet volume was 8.27 ± 1.21 fl in patients with anti-HCV (+) and 7.60 ± 1.10 fl in anti-HCV (-). Statistically significant differences were found between the two groups (p<0.001).

CONCLUSION: HCV infection can cause decreasing in platelet counts in hemodialysis patients. MPV increased in hemodialysis patients who were anti-HCV (+). 

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EISSN 2667-4440