During influenza epidemics, the increase of the number of acute illness leads to applications to outpatient and emergency services, and it also results in increase of hospitalization for treatment of complications of lower respiratory system. Because of high medical treatment costs and the rate of mortality, the effective protective methods should be applied to infection sensitive groups ( High-risk groups ) in communities. Chronic renal failure and renal transplanted patients are one of the high-risk groups. Every year immunoprophylaxis with inactivated vaccine is the most effective method in decreasing the effect of influenza. In this article influenza infection and prevention of influenza with vaccination will be discussed.