Patients treated with hemodialysis are predisposed to infections. Catheter-related infections are the most common infections in patients who have a central venous hemodialysis catheter. These infections may lead to bacteremia or metastatic infection. Cutaneous vasculitis is a form of vasculitis characterized by purpuric eruption localized to the lower extremity. This entity may be related to drugs, infections or have an unknown etiology. Here we present two chronic hemodialysis patients who had fever and increased infection parameters such as leukocytosis and C-reactive protein (CRP). During follow-up, they developed purpuric eruptions on the legs. Infection-related cutaneous vasculitis was diagnosed in these patients and they were successfully treated with antimicrobial therapy.