Turkish Journal of Nephrology
Case Report

Increased Tacrolimus Levels After Administration of Ciprofloxacin to a Patient with Renal Transplant


Haydarpasa Numune Education and Research Hospital, Department of Nephrology, İstanbul, Turkey

Turkish J Nephrol 2016; -1: Supplement 171-174
DOI: 10.5262/tndt.2016.42
Read: 1106 Downloads: 405 Published: 04 February 2019

Tacrolimus is a calcineurin inhibitor that is used to prevent organ rejection following renal transplant. The tacrolimus dose is adjusted based on clinical response and blood concentrations because patient to patient variability exists in both pharmacokinetics and pharmacodynamics. Fluoroquinolones are frequently used for treatment due of their broad spectrum of activity; however, some are reported to increase the blood concentration of calcineurin inhibitors. In this study, we describe a patient who had undergone a renal transplant and experienced a clinically significant interaction between tacrolimus and ciprofloxacin. In this case, the patient required a very low dose of tacrolimus (1 mg/day) to achieve target blood levels. This was probably due to pharmacokinetic diversity related to the CYP3A enzymatic system and high blood levels after ciprofloxacin use. The blood levels of tacrolimus increased after the use of ciprofloxacin and returned to baseline once the drug was discontinued. Health care professionals should be aware of such drug interactions.

EISSN 2667-4440