More than 170 million people are thought to be infected by the hepatitis C virus globally and nearly one million of these patients were die due to cirhhosis and hepatocelular carcinoma every year. Hepatitis C infection is highly prevalent in dialysis patients. Hepatits C infection harms the kidneys by various immunological and non-immunological mechanisms. The prresence of hepatitis C is closely related to increased mortality in dialysis patients. Recent studies have disclosed that hepatitis C infection is also associated with impaired life quality in dialysis patients. The most important problem of hepatitis C infection today is the lack of efficiency and reliability of the drugs used to treat hepatitis C infection in dialysis patients. Large, randomized well-designed studies on the treatment of hepatitis C infection in dialysis patients are still lacking. In the current review, we tried to provide general information about hepatitis C infection in dialysis patients based on the current literature.