Turkish Journal of Nephrology
Original Article

Endothelial Dysfunction and Vitamin D Levels in Kidney Allograft Recipients

1.

Ankara University Faculty of Medicine, Department of Nephrology, Ankara, Turkey

2.

Ankara University Faculty of Medicine, Department of Cardiology, Ankara, Turkey

3.

Ankara University School of Medicine, Department of Pediatric Molecular Pathology and Genetics, Ankara, Turkey

Turkish J Nephrol 2012; 21: 53-59
DOI: 10.5262/tndt.2012.1001.09
Read: 408 Downloads: 235 Published: 08 February 2019

There have been several studies demonstrating a relationship between vitamin D and cardiovascular disease. Vitamin D Deficiency/Insufficiency (D/I) is a common problem in chronic renal disease and also renal transplant recipients, however, there is a variation between the summer and winter periods. We investigated whether there is a relationship between vitamin D D/I and endothelial dysfunction in renal transplant recipients (RTR). We also evaluated vitamin D levels in summer and winter. Flowmediated dilatation (FMD), soluble endothelial protein receptor C (sEPRC) and soluble thrombomodulin (sTM) were chosen for markers of endothelial function. Firty-five patients were recruited to the study. Winter measurements were performed on March, summer measurements were performed in September. In the winter, methe an vitamin D level was 18.8±7.5, compared with 34.3±13.0 ng/ml in the summer period (p<0.0001). There were 38 (84%) and 20 (44%) patients in the winter and summer periods with vitamin D D/I, respectively. We did not find any significant association between vitamin D D/I and FMD, sTM or sEPCR in either period. While vitamin D D/I is a common finding during winter in RTR, it recovers in the summer. Moreover, vitamin D D/I seems not to be associated with endothelial dysfunction.

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