Turkish Journal of Nephrology
Original Article

Effect of Intravenous Active Vitamin-D Treatment on the Left Ventricular Mass Index in Chronic Hemodialysis Patients with Secondary Hyperparathyroidism

1.

Department of Nephrology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

2.

Department of Nephrology, Ufuk University School of Medicine, Ankara, Turkey

3.

Department of Nephrology, Medeniyet University School of Medicine, İstanbul, Turkey

Turkish J Nephrol 2019; 28: 30-33
DOI: 10.5152/turkjnephrol.2019.3137
Read: 582 Downloads: 124 Published: 05 February 2019

Objective: We investigated the effect of active D vitamin therapy on echocardiographic examination results in hemodialysis patients with hyperparathyroidism.

Materials and Methods: This prospective study involved 20 patients  who undergoing HD for a total of 12 hours per week at least 6 months. Patients with serum intact parathormone level (iPTH) ≥20.8 pmol/L, phosphorus level 3.5 - 5.5 mg/dL, calcium level <9.5 mg/dL included in this study.  Before and after 6 months active vitamin D treatment, left ventricular mass index (LVMI) of all patients were  investigated by echocardiography.

Results: The mean age was 51.2±15.0 Ten patients were female and ten patients were male. The mean iPTH level in serum before and six months after active vitamin-D treatment were 35.97±16.41 and 24.92±13.28 pmol/L respectively (p<0.001). Before and six months after active vitamin- D treatment the mean LVMI were 294.40±103.2 gr/m2 and 250.40±101.44 gr/m2 respectively. LVMI was statistically significant decreased after six months treatment compared to before treatment (p<0.001).

Conclusion: Increased serum iPTH levels in patients undergoing HD decrease with active vitamin-D treatment and this results in significant reduction in LVMI. Our results show that treatment of hyperparathyroidism plays an important role in correcting LVH.

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EISSN 2667-4440