Turkish Journal of Nephrology
Orginal Article

Effect of Conductance and Sodium Balance on Inter/Intra-Dialytic Symptoms

1.

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Karnataka, India

2.

Department of Nephrology, Kasturba Medical College, Kasturba Hospital, Manipal Academy of Higher Education, Karnataka, India

Turkish J Nephrol 2020; 29: 52-58
DOI: 10.5152/turkjnephrol.2020.3682
Read: 57 Downloads: 21 Published: 11 February 2020

Objective: To evaluate Patient Reported Outcomes of intra/interdialytic symptoms and to optimize the ideal conductivity settings maintained for minimal symptom expressions.

Materials and Methods: A prospective observational study, carried out in a south Indian tertiary care teaching hospital. Patient Reported Outcomes Kidney Disease Quality of Life (KDQOLTM) 35 Symptom List Questionnaire was administered to each patient to determine inter/intradialytic symptoms coupled with sodium conductivity measurement during hemodialysis.

Results: Of the 126 study populations, 97 consented were involved, the mean age was 50±11 years, with male predominance of 79%. Of the 31 parameters studied, 9 correlated significantly to conductivity showing some relationship (p<0.05). Muscle cramps, muscle soreness, fatigue, trouble sleeping and nausea were least at population conductivity mean of 14.4 mS/m and peaked at the extremes of mean conductivity range of 13.2 and 15.1 mS/m. Whereas hypotensive symptoms and hot & cold spells were lowest at higher extreme of mean conductivity and peaks at lower end due to sodium removal & hyponatremia.

Conclusion: The change in sodium conductivity with response to sodium gradient was associated with significant increases in inter/intra-dialytic symptom rates associated with symptoms like cramps, soreness, fatigue, nausea and trouble sleeping are least severe around a conductivity of 14.5 mS/m.

Cite this article as: Kumar P, Dube A, Sheena Karim B, Rache T, Prabhu Attur R, Nair S, et al. Effect of Conductance and Sodium Balance on Inter/Intra-Dialytic Symptoms. Turk J Nephrol 2020; 29(1): 52-8.

Files
EISSN 2667-4440