Determinants of Mortality Among Elderly Subjects with Chronic Kidney Disease

Objective: Studies on predictors of mortality among elderly chronic kidney disease (CKD) patients have conflicting results. We aimed to assess the factors related to mortality in CKD versus non-CKD elderly subjects. 

Methods: Medical records of consecutive elderly subjects presented to geriatrics outpatient clinics were retrospectively searched. Logistic regression models were set in order to determine independent predictors of mortality. 

Results: The median age was 73 (67-80) years, and 837 (67.9%) were female. CKD constituted 21.9% of the cohort. During the follow-up of 3 to 4 years, 7.2% of the patients died. In the CKD cohort, older age (per year, OR 1.12, 95% CI 1.01-1.25, P = .040) and serum uric acid levels (per 1 mg/dL increase, OR 1.74, 95% CI 1.12-2.69, P = .013) were associated with a higher risk of mortality while serum albumin (per 1 g/dL increase, OR 0.08, 95% CI 0.01-0.52, P = .008) and vitamin D levels (per 1 ng/mL increase, OR 0.77, 95% CI 0.62-0.96, P = .019) were associated with a lower risk of mortality in the multivariate regression model.

Conclusion: Older age, lower serum albumin and vitamin D levels, and higher serum uric acid levels are independent predictors of mortality in outpatient elderly subjects with CKD.

Cite this article as: Heybeli C, Soysal P, Kazancıoğlu R. Determinants of mortality among elderly subjects with chronic kidney disease. Turk J Nephrol. 2021; 30(3): 193-198.