Turkish Journal of Nephrology
Case Report

Cranial Nerve Injury as an Initial Sign of Wegener Granulomatosis: Misdiagnosis and Fatal Course in Two Cases

1.

Mersin University Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Mersin, Turkey

2.

Mersin University Faculty of Medicine, Department of Pathology, Mersin, Turkey

3.

Mersin State Hospital, Department of Dermatology, Mersin, Turkey

4.

Mersin University Faculty of Medicine, Department of Neurology, Mersin, Turkey

5.

Harran University Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Şanlıurfa, Turkey

6.

Mersin University Faculty of Medicine, Department of Radiology, Mersin, Turkey

Turkish J Nephrol 2014; 23: 164-168
DOI: 10.5262/tndt.2014.1002.18
Read: 1222 Downloads: 652 Published: 08 February 2019

Highest prevalence of all antineutrophil cytoplasmic antibody associated systemic vasculitides is the Wegener granulomatosis, and it’s typically characterized by a necrotizing granulomatous vasculitis of the respiratory tracts, kidneys, and skin. Neurologic involvement in Wegener granulomatosis ranges from 22% to 54%, but central nervous system involvement is from 2% to 8%. Cranial nerve involvement as an initial sign with concomitant systemic disease is extremely rare. Involvement of one or more cranial nerves is generally a seemingly isolated finding in Wegener granulomatosis. We present WG cases that presented with treatment-resistant cranial nerve involvement and acute fatal pulmonaryrenal syndrome.

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EISSN 2667-4440