Turkish Journal of Nephrology
Original Article

Could L-Carnitine Treatment Have a Protective Role in the Cognitive Function of Patients Undergoing Hemodialysis?

1.

Department of Nephrology, University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

2.

Department of Biochemistry, University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

3.

Department of Psychiatry, University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

Turkish J Nephrol 2021; 30: 77-83
DOI: 10.5152/turkjnephrol.2021.4747
Read: 33 Downloads: 24 Published: 11 February 2021

Objective:  This study aimed to assess whether the administration of L-carnitine (LC) was effective on the cognitive function of patients on hemodialysis (HD).

Materials and Methods: Results of 33 patients who received 1000 mg of LC intravenously thrice a week for 6 months and 40 patients who did not receive LC were assessed. The mini-mental state exam (MMSE) was used to assess the cognitive function. An MMSE score of <24 was considered to be a cognitive impairment (CI).

Results: The rate of CI was 42.5% in patients on HD. The MMSE score of patients who had received LC was higher than those who did not (24.79±3.577 and 22.70±5.341, respectively, p=0.046). The MMSE score of men was higher than women (24.74±4.374 and 21.78±4.766, respectively, p=0.009). The MMSE score was significantly lower in patients with diabetes than in those without diabetes (20.69±6.343 and 24.47±3.822, respectively, p=0.004). It was demonstrated in the multiple general linear model analysis that age (p<0.001), sex (p<0.001), diabetes (p=0.010), total carnitine (p=0.005), and free carnitine (p=0.003) were independent factors affecting the MMSE scores.

Conclusion: These findings suggest that regular follow-up of serum carnitine levels and replacement of LC could be positive factors in improving cognitive function in patients on HD.

Cite this article as: Atılgan KG, Yalçındağ A, Örsel S, Aylı MD. Could L-Carnitine Treatment Have a Protective Role in the Cognitive Function of Patients Undergoing Hemodialysis?. Turk J Nephrol 2021; 30(1): 77-83.

Files
EISSN 2667-4440